Which breed of dog is most predisposed to osteosarcoma?

Golden Retrievers are notably predisposed to osteosarcoma among dog breeds, making them one of the most commonly affected breeds. This predisposition is primarily attributed to both genetic factors and the breed's inherent size, as larger breeds tend to have a higher incidence of this aggressive bone tumor. Osteosarcoma often occurs in long bones, and the rapid growth and increased skeletal mass associated with larger breeds amplify the risk of malignant transformation in bone cells.

Research studies have consistently shown that Golden Retrievers, among other large and giant breeds, display a significantly higher frequency of this cancer compared to smaller breeds. This predisposition highlights the importance of breed-specific risk factors in the diagnosis and management of osteosarcoma, assisting veterinarians in recognizing and monitoring at-risk individuals for early signs of disease.