Which breed is predisposed to developing transitional cell carcinoma?

Transitional cell carcinoma (TCC) is a type of cancer that commonly arises in the urinary bladder and is particularly noted for its association with certain dog breeds. The Scottish Terrier is one of the breeds acknowledged to have a higher predisposition to developing transitional cell carcinoma. Research indicates that there is a significant breed-related risk, and Scottish Terriers are often cited in veterinary literature as having a marked prevalence of this type of cancer.

This predisposition may be related to genetic factors inherent in the breed, though the exact mechanisms are not fully understood. Factors such as hormone receptors, specific genetic mutations, and particular anatomical traits might contribute to the increased risk in Scottish Terriers compared to other breeds.

Understanding breed predisposition plays a crucial role in veterinary practice, as it helps practitioners recognize at-risk animals and consider early screening or preventive measures in breeds known to be susceptible to certain cancers like TCC.