What factor contributes to the aggressiveness of osteosarcoma in small animals?

Osteosarcoma is notably aggressive due to several factors, and genetic predisposition plays a significant role in influencing its behavior. In certain breeds, such as Great Danes, Rottweilers, and Doberman Pinschers, there is an increased incidence of osteosarcoma, suggesting that hereditary factors can enhance the tumor's likelihood of development and potentially its aggressive characteristics.

Genetic alterations in tumor suppressor genes and oncogenes can lead to uncontrolled cellular proliferation and contribute to the cancer's invasive potential. Understanding these genetic predispositions allows for better risk assessments and may guide further research into targeted therapies or interventions.

While other factors such as high metabolic activity, insulin resistance, and the location of the tumor may contribute to the cancer's overall prognosis and behavior, it is the genetic predisposition that fundamentally underpins the innate aggressiveness of osteosarcoma in small animals, influencing how the disease manifests and progresses.