In oncology, what does the term "unresectable" mean?

The term "unresectable" specifically refers to tumors that cannot be surgically removed due to factors such as size, location, or the extent of disease. This definition is critical in oncology as it helps guide treatment options and decisions. For example, a tumor may be located in a position that makes surgical access difficult or impossible, or it may be so large that removing it would result in significant morbidity or incomplete tumor removal.

Understanding the implications of unresectable tumors is essential for formulating a treatment plan. These tumors often necessitate alternative approaches, such as chemotherapy, radiation therapy, or palliative care, rather than surgical intervention, which is typically the first-line treatment for removable tumors.

The other terms do not accurately capture the essence of being "unresectable.” For instance, a tumor that "cannot be diagnosed" does not relate to its resectability status. Similarly, low response to treatment and the tendency to recur may pertain to tumor behavior, but they do not inherently define whether a tumor is surgical candidate or not.